Adaptive support ventilation prevents ventilator-induced diaphragmatic dysfunction: an in vivo piglet study
نویسندگان
چکیده
منابع مشابه
Adaptive support ventilation prevents ventilator-induced diaphragmatic dysfunction in piglet: an in vivo and in vitro study.
BACKGROUND Contrary to adaptive support ventilation (ASV), prolonged totally controlled mechanical ventilation (CMV) results in the absence of diaphragm activity and causes ventilator-induced diaphragmatic dysfunction. Because maintaining respiratory muscles at rest is likely a major cause of ventilator-induced diaphragmatic dysfunction, ASV may prevent its occurrence in comparison with CMV. Th...
متن کاملModerate and prolonged hypercapnic acidosis may protect against ventilator-induced diaphragmatic dysfunction in healthy piglet: an in vivo study
INTRODUCTION Protective ventilation by using limited airway pressures and ventilation may result in moderate and prolonged hypercapnic acidosis, as often observed in critically ill patients. Because allowing moderate and prolonged hypercapnia may be considered protective measure for the lungs, we hypothesized that moderate and prolonged hypercapnic acidosis may protect the diaphragm against ven...
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Controlled mechanical ventilation induced a profound diaphragm muscle dysfunction and atrophy. The effects of diaphragmatic contractions with assisted mechanical ventilation on diaphragmatic isometric, isotonic contractile properties, or the expression of muscle atrophy factor-box (MAF-box), the gene responsible for muscle atrophy, are unknown. We hypothesize that assisted mechanical ventilatio...
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In the previous issue of Critical Care, Jung and colleagues report on the preventive effects of hypercapnia on ventilator-induced diaphragmatic dysfunction (VIDD) under controlled ventilation. Possibly, a combination of controlled hypercapnia and allowed spontaneous breathing efforts may provide complementary protection for diaphragm and respiratory functionality during mechanical ventilation. ...
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1Department of pediatrics, Chonnam National University Medical School and Hospital, Republic of Korea 2College of Veterinary Medicine, Chonbuk National University, Republic of Korea 3National Institute of Animal Science, Republic of Korea 4Department of Pediatrics, KS hospital, Republic of Korea 5Institute of Animal Medicine, Gyeongsang National University, Republic of Korea 6Department of Thor...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2009
ISSN: 1364-8535
DOI: 10.1186/cc7195